Peptides of neuron specific enolase as potential ASD biomarkers: From discovery to epitope mapping
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چکیده
منابع مشابه
Pepitope: epitope mapping from affinity-selected peptides
UNLABELLED Identifying the epitope to which an antibody binds is central for many immunological applications such as drug design and vaccine development. The Pepitope server is a web-based tool that aims at predicting discontinuous epitopes based on a set of peptides that were affinity-selected against a monoclonal antibody of interest. The server implements three different algorithms for epito...
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Ninety-eight patients treated for breast carcinomas were followed from 54 to 75 months after primary diagnosis. All had undergone a modified radical mastectomy with removal of axillary lymph nodes. 36 breast carcinomas were NSE-positive and 62 were negative. NSE-positive tumours were significantly more frequently estrogen receptor-positive than the NSE-negative tumours, and the estrogen recepto...
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CLINICALCHEMISTRY, Vol. 34, No. 11, 1988 2375 trile, and applied the extract to a SepPak C18 cartridge (Waters Associates, Milford, MA) that had been washed sequentially with acetomtrile and water. To remove 24,25dihydroxy vitamin D, we washed the cartridge with water, then with methanol:water (7:3 by vol). 250HD was eluted with acetonitrile; the eluate was evaporated under nitrogen and the dri...
متن کاملEvaluating blood levels of neuron specific enolase, chromogranin A, and circulating tumor cells as Merkel cell carcinoma biomarkers
BACKGROUND Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin cancer. Although used to monitor MCC patients, the clinical utility of neuron-specific enolase (NSE) and chromogranin A (ChrA) blood levels is untested. EpCAM-positive circulating tumor cells (CTC) reflect disease status in several epithelial tumors. Here we investigate the use of NSE and ChrA blood levels and CTC ...
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ژورنال
عنوان ژورنال: Brain, Behavior, and Immunity
سال: 2020
ISSN: 0889-1591
DOI: 10.1016/j.bbi.2019.12.002